A.V. Grigoriev Art and History Museum, Regional cultural heritage museum in Kozmodemyansk, Russia.

The A.V. Grigoriev Art and History Museum is an art museum in Kozmodemyansk housed in a 19th-century merchant house. The collection holds more than 43,000 objects, including approximately 3,500 artworks displayed across several exhibition halls.

The museum was founded on 7 September 1919, when Alexander Grigoriev saw the Volga-Kama travelling exhibition of 1918 and organised a museum around it. It opened in the merchant Torsuev's house, moved to the Smolensk Cathedral in 1933 and since 1998 has occupied the Ponomarev house, built in 1883. Grigoriev was repressed in 1938; his name was restored to the museum in 1966.

The collection features works by Russian artists from the 19th and 20th centuries, including paintings by Karl Bryullov. It reflects the local artistic tradition and its influence on the region.

The museum occupies the 1883 Ponomarev merchant house, restored for the collection. Its three history rooms cover nature and archaeology, porcelain, and the town's past; the art galleries are separate. The building is a regional heritage site in central Kozmodemyansk.

In 1923 Grigoriev bought several works from Nikolai Feshin before Feshin left for the United States; Feshin also gave him sketches for "Cheremis Wedding". Eleven Feshin works are held here, the largest group by this painter in the region.