William Winston House, Historic residence in Tuscumbia, United States.

The William Winston House is an early 19th-century residence in Tuscumbia that displays classical Federal architectural elements. The building shows balanced proportions, symmetrical windows, and refined details throughout its structure.

Construction began in the early 1800s under merchant Clark T. Barton and was completed in 1824 by planter William Winston. The house stayed in the Winston family until 1948, when it was sold to the city of Tuscumbia, which built the Deshler High School campus around it. It was listed on the National Register of Historic Places in 1982.

The house stayed in the Winston family until 1948, when it was sold to the city of Tuscumbia. Two of William Winston's children linked the house to Alabama politics: John A. Winston was governor from 1854 to 1857, and a daughter married governor Robert B. Lindsay.

The house stands on the Deshler High School campus in Tuscumbia; the sources record no public tours or interior access, so visitors see the brick exterior, five-bay façade and Tuscan portico from the school grounds. It was listed on the National Register of Historic Places in 1982.

The spiral staircase rises from the first floor to the attic without a landing break, a feature tied to the house's center-hall plan. The brick is laid in Flemish bond on all four sides, not only the façade, and the two chimneys on each side serve the hipped roof.