Wiscasset Historic District, Colonial-era historic district in Wiscasset, United States.

Wiscasset Historic District covers 101 acres (41 ha) of the central village of Wiscasset, on the west bank of the Sheepscot River. It holds at least 22 contributing buildings and two contributing sites, including a cemetery whose oldest stone dates to 1739. Most of the Federal-period buildings were raised between about 1780 and 1820, among them the Nickels-Sortwell House, a National Historic Landmark.

The area developed into a major shipping port east of Boston during the American Revolution. Economic decline from the 1807 Embargo allowed the area to preserve its historic structures.

The Nickels-Sortwell House and Castle Tucker display Victorian architecture with ornate details from the 1800s. The Maine Art Gallery occupies a former school building and shows works by local and regional artists.

The district has self-guided walking routes with historical signs, and many buildings offer guided visits from June through October. The best time to visit is during warm weather when most shops and museums are open.

The district's oldest surviving structure is not a house but the Ancient Cemetery, whose earliest existing stone dates to 1739. Among the contributing buildings, the Damon House on Federal Street is owned by Harvard University and administered by the Boston Athenaeum.