Église Notre-Dame Saint-Louis de la Guillotière, Catholic church in Guillotière district, Lyon, France.

Église Notre-Dame Saint-Louis is a church in Lyon's 7th arrondissement built in neoclassical style with a two-story main facade and Tuscan pilasters framing the central opening. Inside, the nave extends through six bays toward a semicircular choir at the far end.

Built between 1842 and 1847 by architect Christophe Crépet, the building replaced an earlier 1619 chapel dedicated to Notre-Dame de Grâce. The new structure represented the religious community's growth in this district during the 19th century.

The church is dedicated to both the Virgin Mary and Saint Louis, and a painting by the Lyonnais artist Angel Joyard showing Saint Louis at prayer, commissioned by the city of Lyon in 1846 and delivered in 1849, hangs at the altar of the right side aisle. A statue of Notre-Dame de Grâce by Joseph-Hugues Fabisch stands at the left aisle altar. On Good Friday a Stations of the Cross procession traditionally sets out from here to Lyon Cathedral.

The building sits at the corner of Rue de la Madeleine and Grande Rue de la Guillotière, making it easy to locate. Regular services and special holiday celebrations form the main schedule for visitors.

The grand organ was built in 1946 by Michel-Merklin & Kuhn in a double case by architect Louis Mortamet, placed on either side of the choir with a separate console. It has three 61-note manuals, a 32-note pedalboard and 39 stops, and was restored in 2008 by Jacques Nonnet of Orgues Giroud.