Michle Synagogue, 18th century synagogue in Prague 4, Czech Republic.

Michle Synagogue is an 18th-century prayer house in Prague 4 with a classical Jewish layout. The interior features a rectangular prayer hall with separate sections for men and women, arranged in a traditional design.

The synagogue's exact construction date is unknown, possibly around 1730, and it is documented only in the 19th century. A late 19th-century rebuild added a neo-Gothic eastern facade and a northern extension with the cantor's flat. After 1922, when Michle joined Prague, the community planned an enlargement that the war prevented; the building later served as a Jewish Museum depository.

The building is no longer used for Jewish prayer; since 1975 it has served as the prayer house of the Albert Schweitzer congregation of the Czechoslovak Hussite Church. A few old gravestones in the small garden in front of the southern facade, said to come from the Jewish cemetery in Uhříněves, are the only reminder of its Jewish past.

The building stands at U Michelského mlýna 124 on the bank of the Botič stream in Michle, Prague 4. It is not a Jewish prayer site: the congregation of the Czechoslovak Hussite Church uses it for its own services, so visits depend on that congregation's arrangements.

The synagogue retained its original architectural configuration while many other Jewish prayer houses in Prague were altered or destroyed. This preservation makes it a rare example of the city's Jewish community heritage.