Grimesland Plantation, Antebellum plantation house in Pitt County, North Carolina.

Grimesland Plantation is a two-story frame dwelling sheathed in weatherboard, with flanking exterior gable-end brick chimneys. One-story hip-roofed wings in the Greek Revival style flank the main block, which also has a two-story rear addition and a one-story front verandah. A row of frame slave quarters and a stone smokehouse stand on the property near Grimesland, Pitt County, North Carolina.

Built about 1790, the house was the home of Confederate general Bryan Grimes (1828-1880) and of 57 enslaved people who worked the farm. It was listed on the National Register of Historic Places in 1971.

The property displays original slave quarters and a stone smokehouse that reflect the agricultural economy and social structures of 19th-century North Carolina. These structures allow visitors to understand the physical layout of plantation life during that era.

The house stands near Grimesland in Pitt County, North Carolina, and is reached by car; the sources give no street address or opening arrangements, so confirm access before travelling. The main house, the row of frame slave quarters and the stone smokehouse sit together on the property, all listed on the National Register in 1971.

Bryan Grimes, born at Grimesland about 1790, was killed in 1880; the house stayed in his family and was listed on the National Register of Historic Places in 1971. The listing covers the main dwelling together with a row of frame slave quarters and a stone smokehouse, so the working layout of the farm survives alongside the house.