Sanford Mills Historic District, Industrial heritage site in Sanford, United States.

Sanford Mills Historic District covers about 7.5 acres bounded by Washington Street, Weaver Drive, Emery Street and Pioneer Avenue, with fourteen buildings along a channelized stretch of the Mousam River. The oldest surviving structure dates to 1882; pre-1890 buildings are mainly wood-frame, while those built after 1910 are brick and concrete.

This site began in 1867 when Thomas Goodall founded a factory to make mohair fabrics, employing many workers for decades. Production halted in 1955 after the Burlington Mills Corporation shut down operations.

The mill buildings reflect changing construction methods across generations, showing how production needs shaped the workspace. The layout along the river reveals the central role water power played in organizing daily factory work.

The complex occupies about 7.5 acres (3.0 ha) bounded by Washington Street, Weaver Drive, Emery Street, and Pioneer Avenue, just north of Sanford's central business district. The Mousam River runs through the site, with two crossings linking its banks. The fourteen buildings stand close together, so walking from the river outward shows how the mill yard was organized.

The Stenton Trust Mill, a 1922 five-story brick and concrete textile complex within the district, burned in June 2017 in the largest fire Sanford firefighters had fought; three local boys were charged with arson, and demolition began in September 2018.