Colegio Ayacucho, Historic school and national monument in La Paz Department, Bolivia.

Colegio de Ciencias y Artes San Simón de Ayacucho occupies a Republican-style building on the site of the former Santo Domingo convent, whose temple still stands. The school is organised around a central courtyard, and a replica of its 1826 founding decree is kept in the patio de honor. The property was declared a national heritage site in 2013.

The Colegio de Ciencias y Artes San Simón de Ayacucho was founded on 28 April 1826 by a decree signed by Marshal Antonio José de Sucre, in the building of the former Santo Domingo convent, whose church still stands. It was funded by convent rents and donations such as those of Francisca Llano, widow of Colonel Protasio Armentia, exceeding 4000 pesos a year. In 1831 the Universidad Mayor de San Andrés was founded on the same site and shared it until 1919, when the university left and the school took sole occupancy.

The central courtyard serves as a gathering space where students and visitors move through the building's daily life. This area reflects the school's role as a formative place for Bolivian leaders across generations.

The site is more accessible to visitors during school holidays, though outdoor areas can often be viewed at other times. It is best to inquire ahead to plan a suitable visit.

At least eleven Bolivian presidents studied here, among them José Manuel Pando, Ismael Montes, Bautista Saavedra and Hugo Ballivián Rojas. A replica of the 1826 founding decree signed by Marshal Antonio José de Sucre is kept in the school's main courtyard.