Former Panama Canal Railway station, Historic railway station building in Santa Ana, Panama City, Panama

The Former Panama Canal Railway Station is a neoclassical building facing Plaza 5 de Mayo in Santa Ana, Panama City. Designed by railway architect H. E. Bartlett and completed in 1913, it has a symmetrical plan with two twin entrances and two separate waiting rooms, one for first class and one for second class. Ten Roman Doric columns still cover the two floors of the facade.

This third railway station at the site was constructed between 1912 and 1913 to serve the growing transportation needs of the canal zone. Operations continued until 1960, when control shifted from United States administration to Panamanian management.

The building's name comes from the Panama Railroad, whose line from Colón was completed on 27 January 1855. Inside, two twin entrances and two waiting rooms kept first- and second-class travellers apart, a reflection of the Canal Zone's rigid caste system. The upper floor held 20 rooms for employees.

The building sits at Plaza 5 de Mayo and is accessible via multiple public transportation routes in Panama City. Guided tours help visitors understand how the railway connected to canal construction and shaped regional development.

From 1976 to 2005, the station housed the Museum of Panamanian People, later renamed the Reina Torres de Araúz Anthropological Museum. This transformation made the space an important venue for sharing cultural knowledge with the public.