House of the Seven Gables, Octagonal house in Mayo, Florida.

House of the Seven Gables was an octagonal residence in Mayo featuring seven gabled sections with one side extending into a rear wing. The structure combined octagonal architecture with traditional residential spaces, containing three bedrooms and a parlor in the main octagonal section while cooking and dining areas occupied the connected wing.

James Mitchell designed the house after reading Nathaniel Hawthorne's novel, and Mack Koon built it in the 1880s at Clark and Bloxham streets in northwest Mayo. In 1989 it was listed in A Guide to Florida's Historic Architecture, prepared by the Florida Association of the American Institute of Architects. A storm later nearly demolished it, and with no restoration plans known, the house was dismantled and the lot cleared.

The house took its name from Nathaniel Hawthorne's novel, bringing literary inspiration into a small Florida community's architectural identity. The octagonal design combined with gabled sections represented a creative expression of classical themes in a local building tradition.

The house stood at the corner of Clark and Bloxham streets in northwest Mayo. It has since been dismantled and the lot cleared, so there is nothing left to visit at the site; the location can still be identified on a town map.

Dr. Charles Hailey of the University of Florida cited the house as an example of adapting "Florida's small-town vernacular structures, 'minor monuments'" that merit research. The house was dismantled and the lot cleared after a storm nearly destroyed it.