The Mary Brogan Museum of Art and Science, Art and science museum in downtown Tallahassee, Florida, US.

The Mary Brogan Museum was a combined art and science museum in downtown Tallahassee that featured two floors of galleries with interactive exhibits and rotating collections. The spaces mixed contemporary art displays with hands-on activities designed for visitors of all ages.

The Museum of Art/Tallahassee (founded 1990) and the Odyssey Science Center (1991) shared a building on Kleman Plaza from 1998, then merged in July 2000. The building was renamed for Mary Brogan, wife of Lt. Gov. Frank Brogan, who died of cancer in 1999. Tallahassee Community College took over the sub-lease in 2003, and the museum closed permanently in 2013.

The museum held Smithsonian Affiliate status, which allowed it to borrow important artifacts for temporary exhibitions that might not otherwise visit Tallahassee. This connection helped attract world-class collections to the region.

The museum occupied two floors of interactive science exhibits plus an art gallery, with a gift shop, educational classrooms and rental space for special events. Tallahassee Community College opened classroom space in the previously dormant basement in 2005, reached by a staircase extending below the first-to-second-floor stairway, next to the Kleman Plaza parking garage.

The museum carried the name of Mary Brogan, an education advocate whose commitment to Florida schools became known through her husband's role as Lieutenant Governor. Her name on the building recognized her personal contributions to arts education rather than simply being a major donor.