Karlshof, Student residence in Darmstadt, Germany.

Karlshof is a residential complex in Darmstadt with furnished rooms in shared flats for two to six people, plus family apartments for those with children. The buildings contain different room sizes and setups to meet various housing needs.

The complex was built to house students from Technical University Darmstadt and Darmstadt University of Applied Sciences. For decades it has served as a home base for the academic community in the city.

The name Karlshof recalls the estate founded in 1779 by minister Carl Ludwig Freiherr von Barkhaus genannt Wiesenhütten, whose garden restaurant was popular with Darmstadt citizens. The Oetingervilla, built by the Oetinger family in 1898, now houses a self-managed youth and culture centre on the site. The student residence itself appears in the film 13 Semester.

The site lies between Kranichsteiner Straße to the west and Alfred-Messel-Weg to the east in the Martinsviertel district, northeast of Darmstadt's centre. The student housing is not open to the public; the separately run Oetingervilla on the grounds is a self-managed youth and culture centre.

The complex has 18 wheelchair-accessible rooms and runs a children's daycare for student parents. This makes it a place that actively supports students with disabilities and those raising families.