Santi Cosma e Damiano, Romanesque shrine and church in central Genoa, Italy.

Santi Cosma e Damiano is a Romanesque church in Genoa's Molo quarter, reached through narrow alleys below the Castello hill. Its interior has three naves divided by six columns of white and black stone segments with acanthus-leaf capitals, plus two cross-shaped transept piers and three shallow apses. The oldest parts are in Promontorio stone, later structures in exposed brick. The facade is tripartite, with three 12th-century arcosolium tombs and the pointed-arch "tomba del Barisone" in white and black bands.

First documented on 21 April 1049, the church was probably built that year, though tradition holds a Lombard-era chapel to Saint Damian stood here earlier. It became a parish around 1147, and in 1296 relics of Saint Damian brought from Constantinople prompted the joint dedication to Cosmas and Damian. The French naval bombardment of 1684 destroyed the wooden truss roof, replaced by masonry cross vaults; bombs in November 1942 hit the left transept wall, the roof and an interior column.

The church keeps paintings tied to Genoese masters: Bernardo Castello's Esther and Ahasuerus (16th century), Jochino Assereto's Madonna and Child with Saints Cosmas and Damian healing the sick (17th century), Giovanni Andrea De Ferrari's Transit of Saint Joseph and Barnaba da Modena's Madonna del Soccorso (14th century). A marble Immaculate by Pierre Puget stands among the sculptures.

The church is open to visitors during regular hours and you can explore the interior at your own pace. For information about guided tours or specific access times, check with the local tourism office before your visit.

The church honors Saints Cosmas and Damian, two martyrs who served as protectors for medical practitioners and barbers in medieval times. This dedication shows how craft guilds chose their patron saints and built connections to the church for spiritual protection.