Santa Croce e San Camillo de Lellis, Baroque church in Portoria district, Genoa, Italy.

Santa Croce e San Camillo de Lellis is a baroque church with a Greek cross layout and an octagonal dome at its center. The structure features a rectangular bell tower and classical Doric columns that define its architectural character.

Construction of this church began in 1667 under architect Carlo Mutone, with the facade completed in 1682. The building suffered damage during World War II and underwent major restoration work afterward.

The church keeps the Trionfo della Croce cycle, frescoed by Gregorio De Ferrari with his son Lorenzo in the early 18th century: L'Invenzione della Croce in the apse, the Cross borne by angels in the drum, and Patriarchs, Prophets and biblical heroines in the dome. Quadraturist Francesco Costa painted the architectural frames. Two canvases predate the building: Sant'Elena che adora la Croce by Giovanni Battista Baiardo on the main altar and Il centurione by Valerio Castello.

The church sits on Piazzetta San Camillo in central Genoa and remains an active place of worship. Visitors can reach it on foot from the city center and explore the interior during opening hours.

This building underwent substantial restoration in the 1950s following bomb damage from World War II. Additional renovation work carried out in the early 2000s preserved the baroque qualities of the structure for future generations.