Santa Maria in Monterone, Church building in Sant'Eustachio district, Rome, Italy.

Santa Maria in Monterone is a church building in the Sant'Eustachio district of Rome, featuring three naves separated by eight ancient Ionic columns. The interior is covered by a barrel vault topped with a triangular pediment.

The church's origins are unknown; it may have stood on the ruins of a 1st-century BC pagan temple. It first appears in an 1186 bull of Pope Urban III as a daughter-church of San Lorenzo in Damaso. Restored in 1245 and again in 1597, when it was raised to escape Tiber floods, it was completely rebuilt in 1682 under Innocent XI. It remained a parish until Leo XII transferred the parish to Sant'Eustachio.

The high altar displays an 18th-century painting of Madonna between Saint Peter Nolasco and Saint Peter Pascasio, attributed to Pompeo Batoni. This artwork is one of the religious decorations visible when entering the interior.

The church is on Via Santa Maria in Monterone in the Sant'Eustachio district, a short walk from the Pantheon and Piazza Navona. The nearest bus and tram stops are along Corso Vittorio Emanuele II and Largo di Torre Argentina. The interior is small and usually open during daylight hours; it is an active place of worship, so visits may be limited during Mass.

The church's name comes from the Monteroni family of Siena, who founded it together with a small hospice for pilgrims from Siena. The hospice stood beside the church, and the Redemptorist monastery next door now serves the church.