Holy Trinity Orthodox church in Nizhny Novgorod, Eastern Orthodox church in Vysokovo district, Nizhny Novgorod, Russia.

Holy Trinity Church in Vysokovo is a square-planned Orthodox church with a bell tower and five onion domes set on low drums. It was built in 1801–1815 to a design by architect Ivan Mezhetsky, with a strictly axial layout of altar, prayer hall, refectory and tall bell tower. Besides the main Trinity altar it has a side altar dedicated to the Protection of the Mother of God.

The church was built between 1801 and 1815 to a design by architect Ivan Mezhetsky, replacing an earlier church in Vysokovo. Metropolitan Benjamin of Nizhny Novgorod initiated the construction, and his successor Moses consecrated the finished building in 1815. Vysokovo belonged to the Nizhny Novgorod metropolitans from 1672 and was incorporated into the city in 1929. The church stayed open through the Soviet period, closing for only two and a half months before reopening on the 40th day of the war in 1941, and held cathedral status from 1943 to 1974.

The church keeps the name of the village of Vysokovo, which belonged to the metropolitans of Nizhny Novgorod from 1672 and was absorbed into the city in 1929. Its side altar is dedicated to the Protection of the Mother of God, and a Sunday school for children has operated here since 1997. Venerated in the building are old icons of Christ, the Mother of God and St Nicholas, and a cross brought from the Solovetsky Monastery.

The church stands on Ovrazhnaya Street in the Vysokovo area, with the Vysokovo cemetery beside it. It has remained in continuous use since its consecration, so visits should be timed around services. The building is a regional cultural heritage site.

The church kept its doors open through the Soviet period, closing for only about two and a half months before reopening on the 40th day of the war in 1941. From 1943 to 1974 it held the rank of cathedral, and in 1942 it was the only working church in a large part of Gorky, drawing more than 5,000 worshippers.