Vermilyea Inn Historic District, Historic district in Aboite Township, United States.

The Vermilyea Inn Historic District near Fort Wayne, Indiana, contains one contributing building, the Jesse Vermilyea House, and three contributing structures. The house is a two-story, three-bay Federal style brick dwelling built in 1839, with an original two-story, four-bay gable-roofed wing, a 1+1⁄2-story wood and brick garage addition from about 1945, and a 1+1⁄2-story brick addition from about 2000. The other resources are the visible earthworks of the Wabash and Erie Canal and the timber platform of the canal aqueduct.

The site was established in the 1830s and served as an important point along the Wabash and Erie Canal. Remains of the canal infrastructure, including a timber platform of the canal aqueduct, are still visible on the grounds today.

The buildings show how early Indiana settlers built and decorated their homes in the 1830s. Visitors can see the craftsmanship and local building traditions of that era reflected in the structures.

The district lies southwest of Fort Wayne in Aboite Township, with the Jesse Vermilyea House and the canal earthworks and aqueduct timber platform as its contributing resources. The house is a private dwelling, so the visible canal remains along the grounds are what a visitor can see from outside. The site was listed on the National Register in 2005.

The original building worked both as a home and a lodging place for travelers moving along the canal route. This made the site a central meeting point for people passing through the area.