One Fifth Avenue, Art Deco residential building at Fifth Avenue and 8th Street, Greenwich Village, United States.

One Fifth Avenue is a 27-story building with contrasting colored bricks located at Fifth Avenue and 8th Street in Greenwich Village. The structure serves as an apartment building with a doorman, and contains residential units that define this corner of the neighborhood.

Developer Joseph G. Siegel leased the southeast corner of 8th Street and Fifth Avenue from Sailors' Snug Harbor in 1926, and construction of Harvey Wiley Corbett's design began that year. The 27-story apartment hotel opened in 1927 with two- and three-room units, drawing both praise and controversy. It was converted to a co-op in 1976.

The building's address sign is spotted by the orphans of Miss Hannigan's orphanage in the 1982 film Annie while they search for 987 Fifth Avenue. The now-closed One Fifth Restaurant on the site appeared in Woody Allen's 1989 Crimes and Misdemeanors and in the 1978 film An Unmarried Woman. Candace Bushnell's 2008 novel One Fifth Avenue is named for and set in the building.

The building is a private cooperative, not open to the public, so viewing is limited to the exterior at the southeast corner of Fifth Avenue and 8th Street. The flat facade uses bricks of different colors to create an illusion of depth, best seen by walking along Fifth Avenue and looking up. The address sign at the entrance is the one the orphans seek in the 1982 film Annie.

The address sign of One Fifth Avenue appears in the 1982 film Annie, where the girls from Miss Hannigan's orphanage find it while searching for 987 Fifth Avenue. The building also appears in Niles Spencer's painting Behind the Square.