Tower 280, Office and residential building in downtown Rochester, United States.

Tower 280 is an 18-story office and residential building in downtown Rochester standing 251 feet (76 meters) tall. The structure houses apartments, office spaces, and retail shops on its lower floors, served by eight elevators.

Midtown Tower was built in 1962 as part of Midtown Plaza, housing a 78-room hotel, offices and the 14th-floor Top of the Plaza restaurant and nightclub. The hotel closed in 1980 and the restaurant in 2000 as the mall declined. When Midtown Plaza was demolished for the cancelled PAETEC headquarters, the tower's steel frame was kept and fitted with a modern façade, reopening as Tower280 at Midtown.

The building's name recalls Midtown Plaza, the 1962 shopping mall it once anchored. In 2025 the Clock of Nations, designed by Gere Kavanaugh and a focal point of the mall before its demolition, was moved from storage into the lobby, where visitors can now see it. The Italian restaurant Branca occupies part of the ground levels.

Tower 280 stands at 280 East Broad Street in downtown Rochester, on the site of the former Midtown Plaza. The lower three levels hold retail space and the Branca Italian Restaurant, with offices and apartments above. Colliers Engineering & Design and Brand Networks are among the tenants. The lobby now displays the Clock of Nations, moved there from storage in 2025.

The Top of the Plaza restaurant and nightclub on the 14th floor hosted jazz acts such as Buddy Rich, Dizzy Gillespie, Count Basie and Sarah Vaughn. The hotel closed in 1980 and the restaurant, after several format changes, shut for good in 2000. In 2025 the Clock of Nations by Gere Kavanaugh, a focal point of Midtown Plaza, was moved from storage into the lobby.