Sala Zitarrosa, Cultural venue in Centro district, Montevideo, Uruguay.

Sala Zitarrosa is a multifunctional arts center and music venue located in the Edificio Rex building at Avenida 18 de Julio 1012 in downtown Montevideo. The space hosts jazz festivals, tango dance events, theater productions, film screenings, and musical performances throughout the year.

The Rex Theatre opened in 1928 in the Edificio Rex, designed by architect Alfredo Jones Brown for Max Glücksmann's cinema company. The cinema closed in the 1980s and was bought by the Intendencia de Montevideo, which converted it into a theatre. Restoration led by architect Conrado Pintos under Eneida de León created a 531-seat hall, inaugurated in November 1999 and named after Alfredo Zitarrosa.

The name honours Alfredo Zitarrosa, the Uruguayan singer-songwriter and guitarist. In the early 2000s El Cuarteto de Nos played here repeatedly, from 2001 to 2004, and an unauthorised bootleg of the 2002 and 2003 shows circulated. La Tabaré Banda also performed its theatrical rock "operetas" on this stage.

The venue is managed by Montevideo's Department of Culture and provides spaces for both established and emerging artists. Its central location on Avenida 18 de Julio makes it easy to access by foot or public transport.

The venue runs specialized programs like Ciclo CAUCE and Guitarra Negra that help nurture emerging musical talent in Uruguay. These initiatives give artists a platform to develop their craft and reach wider audiences.