Teatro Florencio Sánchez, National historic theatre in Paysandú, Uruguay.

Teatro Florencio Sánchez is a cinema and theatre in Paysandú whose facade was replaced in an Art Deco style during the 1915–1917 remodelling by architects Jacobo Vázquez Varela and Daniel Rocco. The building was designed by Francisco and Bernardo Poncini and later adapted into a film screening hall. It is a National Historical Monument.

The building opened as Teatro Progreso in 1876 and underwent major renovations in 1915. It received its current name in 1921 to honor the Uruguayan playwright Florencio Sánchez.

The theatre's name, adopted in 1921, honours the Uruguayan playwright Florencio Sánchez. Its stage has hosted the Italian opera company of Lea Candini and Salvatore Sidivo, the Podestá acting family, Carlos Gardel and Ariel Ramírez. In 2011 a Commission of Friends of the Theatre was formed, including former mayor Walter Belvisi, to support its recovery.

The municipality manages the theater and hosts regular performances, film screenings, and cultural events throughout the year. Visitors should check ahead to learn what shows are scheduled during their visit.

The venue was the first location where the complete score of the Uruguayan National Anthem was performed, happening in 1915. This event gives the theater a special place in the nation's history.