Our Lady of Guadalupe Shrine, Aguascalientes City, Aguascalientes State, Mexico, Catholic shrine in Central District, Aguascalientes, Mexico.

The Templo del Santuario de Nuestra Señora de Guadalupe is an 18th-century Catholic church in the Barrio de Guadalupe, begun in 1767 and completed in its first stage in 1789. Its Mexican Baroque frontispiece is carved with stone filigree, and the dome is covered outside with Talavera tiles from Puebla. The interior holds a 1777 painting of the Virgin by José de Alcíbar and a pulpit carved from Tecali onyx with reliefs of the four Evangelists.

The building was constructed in 1767 and stands among the earliest Catholic structures in the Aguascalientes region. Its creation marked an important moment in the religious development of the city during the colonial period.

The neighbourhood was called "de los Arellano" before taking the name of the Guadalupe devotion, and the temple grew out of the shops, inns and warehouses that lined the commercial and farming route. Inside, the pendentives carry paintings of the four apparitions of the Virgin, and a 1777 canvas by José de Alcíbar reproduces the original image with its rays and stars, inscribed "Josef de Alzíbar, Pinxit, 1777".

The shrine stands in the Barrio de Guadalupe, east of the city centre, on the site of the old "de los Arellano" neighbourhood. Visitors enter the 18th-century temple through the main door beneath the stone frontispiece; the 1973 towers and the neo-Gothic Santísimo chapel are best seen from the adjoining plaza. The interior was restored from 2018 under INAH supervision, so some areas may be closed while work continues.

The shrine houses original 18th century paintings depicting the Virgin's apparitions along with other religious artworks from that period. These historical pieces offer insight into the artistic and spiritual traditions of colonial times.