Hernando de Soto Bridge, Road bridge over the Manatee River between Palmetto and Bradenton, Florida, USA

The Hernando de Soto Bridge carries U.S. Highway 41 and U.S. 301 over the Manatee River, linking Palmetto and Bradenton, Florida. It stands 40 feet (12 m) tall and carries four lanes of traffic. It is one of two bridges between the two cities; the other, the Green Bridge, crosses about half a mile (0.8 km) downstream.

The Hernando Desoto Bridge opened in 1957, built to realign US 41 and US 301 through Bradenton and Palmetto. Before that, both routes crossed the Manatee River just downstream on the original Green Bridge, part of which became a fishing pier after its 1986 replacement.

The bridge takes its name from Hernando de Soto, the Spanish explorer associated with the Mississippi region, though this crossing spans the Manatee River between Bradenton and Palmetto. It is one of two river crossings linking the two cities, the other being the Green Bridge about half a mile downstream.

The bridge carries four lanes of US 41 and US 301 between Bradenton and Palmetto. The parallel Green Bridge, about half a mile downstream, is the alternative river crossing. The deck stands 40 feet (12 m) above the Manatee River.

The Desoto Bridge is one of only two crossings between Bradenton and Palmetto; the other, the Green Bridge, stands about half a mile downstream. Before 1957, US 41 and US 301 crossed the Manatee River on the original Green Bridge, part of which survives as a fishing pier after its 1986 replacement.