Waucquez Building, Art Nouveau department store in Pentagon, Brussels.

The Waucquez Building is a former department store in Art Nouveau style located at Rue des Sables 20 in Brussels's Pentagon district. Large bay windows framed with stone sculptures and ironwork displaying palm leaf patterns dominate the facade, while the interior spans multiple floors connected by elegant staircases beneath glass-roofed galleries.

Charles Waucquez commissioned Victor Horta in 1902 to build a new warehouse for his wholesale cloth trade, as his building on Rue de l'Étuve was being expropriated. The structure was built between 1903 and 1906, possibly completed by Horta's collaborator Charles Veraart, who added mezzanines and electric lighting in 1912–1913. After the last tenant left in 1965, the building stood empty until it was restored and reopened as the Belgian Comic Strip Center on 6 October 1989.

Since 6 October 1989 the building has housed the Belgian Comic Strip Center, founded in 1984 by Guy Dessicy and Jean Breydel. Visitors pass beneath Horta's glass domes and along mosaic floors bordered with a floral motif that repeats in the ceiling glazing. The name Waucquez recalls Charles Waucquez, whose family firm Delatre-Waucquez, founded by his father Jean-Baptiste (1818-1871), traded cloth here.

The building sits centrally in the Pentagon district and is easily reached by public transportation. Multiple staircases and elevators provide access to all exhibition levels, where the artistic design of the stairs themselves becomes part of the visiting experience.

The building is one of only two surviving Victor Horta shops in Brussels, alongside the former Wolfers frères store on Rue d'Arenberg; the Innovation and Grand Bazar Anspach stores were demolished. Horta's collaborator Charles Veraart is thought to have completed it and added the mezzanines and electric lighting in 1912-1913.