Avenue Jean-Médecin, Main commercial avenue in central Nice, France.

Avenue Jean-Médecin runs north from Place Masséna to the Marseille–Ventimiglia railway line, where the Passage Max-Vérola continues under the tracks toward Avenue Malausséna. The roadway is paved in grey and crossed by two pairs of steel tram rails converging toward the distance, with pale stone kerbs and pavements along the edges. Black metal poles down the centre carry overhead wires, and multi-storey buildings with pale stone facades, rows of windows and iron balconies line the sides.

Construction began in 1864 under Sardinian rule as a connection between the old town and the railway station. Following annexation to France in 1860, it bore various names, including Avenue de la Gare. The current designation was adopted in 1966 to honor Mayor Jean Médecin, who served from 1928 to 1965.

Locals call it "l'Avenue", and it is Nice's main shopping street, with the city's big department stores and the Nice headquarters of major French banks. The lower, Masséna end is more tourist-oriented, the upper part more of a neighbourhood artery. The avenue long hosted the flower parades of the Nice Carnival, whose floats rolled down to Place Masséna; the tramway and its overhead wires now make this impossible.

Tram lines 1 and 2 operate daily from 4:30 AM to 1:30 AM, with stops along the entire route. Most shops open Monday through Saturday from 10 AM to 7 PM. Public restrooms are located inside Centre Commercial Nice Étoile in the middle of the thoroughfare.

The blue light in the middle of the avenue is not a projection onto facades: thousands of blue diodes are set into the ground itself, lighting up at night. The work, L'Amorse du bleu by light artist Yann Kersalé, was inaugurated when the tramway works ended, and it is the tramway's own overhead wires that ended the carnival floats' descent down the avenue.