Palazzo Spinola, Renaissance palazzo in Milan, Italy.

Palazzo Spinola is a 16th-century palazzo at Via San Paolo 10 in Milan, built in three campaigns between 1570 and 1615 by an unknown architect, with Martino Bassi's participation now considered certain. Its pale, rough-textured stone facade rises from a dark stone base, with a central arched portal framed by rusticated blocks and tall barred windows on either side. Two upper storeys carry evenly spaced rectangular windows beneath a projecting cornice with a carved frieze.

Construction began in 1570 under the commission of Genoese banker Leonardo Spinola and finished in 1615. The long building period reflects the scale and ambition of the project for this wealthy family.

The Sala d'oro was designed by Gerolamo Arganini and decorated by Giacomo Tazzini, with gilded stuccoes on an ivory ground and frescoes. It was remodelled for the wedding of Emperor Ferdinand I and is ringed by a colonnade with friezes carrying an entablature that formed the orchestra tribune. The 1943 fire left only its walls; the Sala d'argento takes its name from Luigi Tatti's silver stuccoes.

The building sits at Via San Paolo 10 in Milan's Porta Nuova district and has served as the headquarters of the Garden Society since 1808. Keep in mind it functions as an active administrative office, so access may be limited.

The painter Luigi Conconi (1852–1917) kept his large studio in Palazzo Spinola until his death, sharing it for years with Gaetano Previati (1852–1920). The two artists worked there while the palace was already the seat of the Società del Giardino.