Odeon Multisala, Italian national heritage cinema near Duomo, Milan, Italy.

Odeon Multisala is a cinema on Via Santa Radegonda in central Milan, a short walk from the Cathedral. It has ten screening rooms of different sizes spread across several floors of the building.

The Odeon was built between 1927 and 1929 on the site of the Santa Radegonda power station, Italy's first thermoelectric plant, demolished in 1926. Designed by Giuseppe Laveni and Aldo Avati with backing from the Pittaluga film family, it opened on 26 November 1929 with an invitation-only preview attended by city authorities. Hit in the August 1943 bombings, it reopened on 7 November 1943 and hosted concerts by the La Scala orchestra while the theatre was damaged.

The Odeon regularly screens films in their original language with subtitles, which draws a crowd different from typical multiplex audiences. This habit has made it a meeting point for film lovers in the center of Milan.

The cinema sits just behind Milan Cathedral and is easy to reach on foot from most of the city center. Tickets can be bought online in advance, and the building is accessible for people with mobility needs.

The main auditorium of the Odeon still has an ornate Art Deco ceiling that survived the renovations of the 20th century. This room is one of the few surviving examples of that style inside a working cinema in Milan.