Madonna di Loreto, Spoleto, Renaissance church in Spoleto, Italy

Madonna di Loreto is a Renaissance church in Spoleto with a symmetrical Greek cross layout and a simple facade decorated with pilasters. The building is connected to a long covered portico that stretches in front of it.

Construction of this church began in 1572 following the designs of Florentine architect Annibale de Lippi near the Porta San Matteo gate. It was built during a period when pilgrimage churches were being constructed across Italy to support popular devotion.

The name comes from the Santa Casa of Loreto, which Jacopo Spinelli's 1537 chapel imitated. Tradition holds that on 21 April 1571 the Madonna's eyes moved during an earthquake swarm, which then ceased; she became the city's protector against earthquakes. Exorcisms drew possessed people from many places, and priests cared for pilgrims day and night.

The church stands outside Spoleto's old walls by the Porta San Matteo, also called Porta Loreto, so it is reached on foot from that gate rather than from the historic centre. The entrance portal on the piazza dates to 1662. The planned dome and the portals on the other two facades were never built, so the exterior reads as a compact, nearly square block.

Inside the church stands a reproduction of the Santa Casa di Loreto, creating a connection to a famous pilgrimage destination elsewhere in Europe. This replica allowed believers who could not travel to pray at this sacred site.