Sant'Ansano, Spoleto, Neoclassical church and archaeological site in Spoleto, Italy

Sant'Ansano is a neoclassical church built in the late 1700s by Milanese architect Antonio Dotti, next to the Arco di Druso in Spoleto. Its single nave is flanked by four large half-columns on the facade, with a rectangular window above the central entrance. The church incorporates a Roman temple of the 1st century AD, whose cella wall forms the church's outer wall.

The first church rose over the tomb of Isaac, a Syrian hermit who came to Spoleto in the first half of the 6th century and founded a community of hermit-monks at Monteluco. The present neoclassical church was built in the late 1700s by the Milanese architect Antonio Dotti. Excavations in 1955–1957, led by superintendent Umberto Ciotti, uncovered a Roman temple of the 1st century AD beneath the church.

The church is dedicated to Saint Ansanus, a patron of Siena, while the crypt below carries the name of Isaac of Monteluco, the Syrian hermit whose tomb stood here. Inside, a fresco by Giovanni di Pietro, called Lo Spagna, shows the Madonna and Child with two saints, and the main altarpiece depicts the Martyrdom of St Ansano by Archita Ricci.

The crypt lies below the church floor and is reached by the ancient Roman temple staircase, whose steps connect the two levels. The west side of the complex, facing Piazza del Mercato, opens onto the excavated temple platform; the church entrance is on the opposite, southern side.

The circular well found beneath the church predates the Roman temple: the temple's stylobate was deliberately interrupted at that point, probably to keep the well in use. Excavations in 1955-1957 also uncovered two parallel corridors paved in opus spicatum, perhaps public passages or shops.