Church of Saint Mary of Jesus, 15th-century Roman Catholic church in Alcamo, Italy.

The Church of Saint Mary of Jesus is a fifteenth-century religious building in Alcamo featuring a marble entrance portal completed in 1507. Inside, multiple chapels display artworks and sculptural pieces gathered over centuries.

Construction started in 1450 under the direction of Blessed Arcangelo from Calatafimi, who also established an adjacent Franciscan convent. The marble portal was added in the early sixteenth century, marking a phase of artistic expansion.

The marble statue of Saint Mary of Jesus on the high altar is attributed to Bartolomeo Berrettaro and Giuliano Mancino. On the first altar on the right hangs the Madonna delle Grazie of 1515, assigned to Pietro Ruzzolone, showing the Virgin with the Child, Saints Francis and Benedict, and the kneeling donors Federico Enriquez and Anna I Cabrera with their pages and damsels.

The church stands in Alcamo, in the province of Trapani. The presbytery was reordered in 1997 by architect Vincenzo Settipani, who renewed the altar, ambo, baptismal font, candelabrum and celebrant's seat and designed the lighting. Enter from the marble portal of 1507; the marble holy water font of the 16th century is on the right, the baptistery with Giuliano Mancino's Saint John the Baptist on the left.

Below the painting of the Madonna delle Grazie, on the first altar to the right, a glass urn holds the remains of Blessed Arcangelo Placenza, moved here in 1961 from the Church of San Michele Arcangelo in Calatafimi. A side wall nearby displays his tombstone, carved with the book of the Rule held between his hands.