Palazzo Isolani, Renaissance palazzo in Santo Stefano, Bologna, Italy.

Palazzo Isolani is a Renaissance building in Bologna with a three-story facade supported by five arches and rectangular windows topped with curved ornaments. The interior courtyard from the 1500s features a spiral staircase that remains intact from that period.

The building received its current appearance in 1708 when Count Alamanno Isolani commissioned architect Giuseppe Antonio Torri to redesign it. This renovation shaped the structure as it stands today.

The ground floor displays frescoes by Francesco Stagno and Giuseppe Valliani alongside family portraits and a painting of King Joachim Murat of Naples. These works reflect the artistic decoration that distinguished the homes of wealthy families.

The palace stands at Via Santo Stefano 16, facing Piazza Santo Stefano, and its ground-floor portico is open to the street. Passing through the interior galleries, the Corte Isolani, leads to shops and a boutique hotel. The Isolani family, originally from Cyprus, still owns the structure.

The 1500 property transfer record describes the house as having a marble fountain in its garden and a chapel for saying Mass, elements that predate the present palace. The helical staircase inside, built in 1500 and attributed to Jacopo Barozzi da Vignola, was later remodelled.