Horry-Guignard House, Federal style residence in Columbia, United States.

The Horry-Guignard House is a two-story Federal style residence in Columbia with a white facade extending across five bays and a balustraded porch supported by square columns running along the entire front. The structure shows classical proportions and symmetrical design typical of homes built in this era, with carefully detailed architectural elements throughout.

The house was built before 1813 and originally belonged to Revolutionary War Colonel Peter Horry. It later passed to John Gabriel Guignard, who served as South Carolina's Surveyor General.

The house is linked to John Gabriel Guignard, South Carolina's Surveyor General from 1798 to 1802, who laid out the first streets of Columbia. An urban legend holds that during the Civil War a slave named Dilcie stayed behind, invited General Sherman to dinner and promised the best cooking in Columbia; Sherman reportedly ordered the home spared in gratitude.

The house is located on Senate Street and forms part of the University of South Carolina School of Law complex. Visitors can view it from the street to see the exterior architecture and details of the building.

During the winter of 1813–1814, the main hall was widened from six feet to eleven feet by sawing the house in half and pulling the two ends apart onto two new foundations. The work dates to that winter, not to 1813 alone.