Old Campus District, University of South Carolina, Historic district at University of South Carolina, United States.

The Old Campus District of the University of South Carolina is a historic district in Columbia, South Carolina, grouping the university's oldest buildings around a central lawn enclosed by brick structures. The buildings were built mostly in the Greek Revival and Classical Revival styles, and the district also contains the McKissick Museum, which holds permanent collections of minerals, artifacts, and decorative arts.

The district was listed in the National Register of Historic Places on June 5, 1970, under reference #70000596, bounded by Pendleton, Sumter, Pickens and Green(e) Streets. Its period of significance spans 1800 to 1874, and the register credits Robert Mills among the architects working in the Early Republic style. The listed functions are education and recreation, including the Maxcy Monument.

The Horseshoe is the curved lawn at the centre of the district, framed by the oldest brick buildings and crossed daily by students and staff. On 19 April 1996 MTV Unplugged filmed Hootie & the Blowfish there, before the release of their second album Fairweather Johnson. The Maxcy Monument stands within the district, which is listed for education and recreation.

The district is bounded by Pendleton, Sumter, Pickens and Greene streets, with The Horseshoe at its centre, so enter on foot from any of these edges. The McKissick Museum and the South Caroliniana Library sit within the district; the library serves research visits. Weekday term-time walks show the campus in routine use.

The 1996 MTV Unplugged taping on The Horseshoe came before Fairweather Johnson, the band's second album, was released. The district's National Register listing dates from June 5, 1970, and covers the blocks bounded by Pendleton, Sumter, Pickens and Green(e) streets.