Provincial Museum of Natural and Oceanographic Sciences, Natural sciences museum in Puerto Madryn, Argentina.

The Provincial Museum of Natural and Oceanographic Sciences occupies the Chalet Pujol, known as the "Castillo de Madryn", built between 1915 and 1917 for the Spanish merchant Agustín Pujol. Its nine exhibition rooms, under the theme "El hombre y el mar", display Patagonian flora and fauna, material from the Tehuelche and Mapuche peoples, and items from European explorers. The museum also has a library, a lookout point and temporary exhibitions.

The Chalet Pujol, known as the "Castillo de Madryn", was built between 1915 and 1917 for the Spanish merchant Agustín Pujol (1870–1927). His family donated it to the provincial government on 16 February 1970, and the museum opened there on 22 February 1972. The building was restored and refurbished in 2005.

The nine rooms are named for their themes, among them Tehuelche Myths and Legends, Myths and Legends of Europeans, European Travellers and Naturalists, Patagonian and Argentine Identity, Botany, Painted Hides and Textiles, and Artisanal Fishermen. The displays set Tehuelche and Mapuche material beside that of European explorers, following the museum's aim of showing the relation between people and nature.

The museum is located at Domecq Garcia 517 and open on weekdays during regular hours. Visitors should allow enough time to explore the different exhibits and the building itself.

From the museum's tower, visitors can watch ships entering Golfo Nuevo while learning about marine life. This vantage point connects the view of the working harbor with the exhibits inside.