Hotel Nacional de Montevideo, Cultural heritage monument in Ciudad Vieja, Uruguay.

Hotel Nacional de Montevideo is a four-story building in Ciudad Vieja, on the streets Piedras, Cerrito, Ing. Monteverde and Lindolfo Cuestas. It was built from 1888 to 1890 in an eclectic-historicist style with marked Italian influence, designed by architect Juan Tosi. The building is 17 meters high and covers a ground area of 2,438 m².

Designed by Italian architect Juan Tosi for Emilio Reus, the building was completed in 1890 but never opened as a hotel because of the 1890 economic crisis. In 1895 it became the seat of the University of the Republic, later housing the faculties of Mathematics, Architecture and Humanities until 1980. It was declared a National Historic Monument in 1996 and has stood vacant since around 2008.

The building's name, Hotel Nacional, recalls its never-realized hotel purpose; locals instead knew it as a university seat from 1895. The Faculty of Mathematics and Annex Branches, the Faculty of Architecture and the Faculty of Humanities and Sciences each occupied it in turn, the last until 1980. Since 1996 it has been a National Historic Monument.

The monument sits within easy reach from Ciudad Vieja's central areas and is visible from nearby streets. Since the structure remains empty, take time to view its exterior architecture and details from the surroundings rather than trying to access the inside.

The structure was originally planned as part of a medical and hydrotherapy complex in the southern section of Ciudad Vieja. This ambitious vision never fully materialized, leaving only this building as a reminder of what was once imagined for that area.