Table Bay Nature Reserve, Protected nature reserve in Milnerton, South Africa.

Table Bay Nature Reserve is an 880-hectare protected area in Milnerton, Western Cape, made up of five constituent reserves: Rietvlei Wetland Reserve, Diep River Fynbos Corridor, Zoarvlei Wetlands, Milnerton Racecourse Nature Reserve and Milnerton Lagoon, plus surrounding protected land. Its central feature is the Rietvlei wetland system, and the reserve holds a large share of Cape Town's remaining critically endangered lowland habitat.

The reserve was created in 2012 by merging several existing protected areas to strengthen conservation efforts in Cape Town's urban landscape. This consolidation of separate reserves allowed for better protection of the region's fragile wetland ecosystems and their vulnerable species.

The reserve takes its name from Table Bay, the bay it borders. Its Rietvlei section is named after the reed beds of the wetland system at its centre. The City of Cape Town's Environmental Resource Management Department runs the reserve from offices at Rietvlei, and the WWF for Nature – South Africa owns two of the erven, managed by the city on a 99-year lease for conservation.

The reserve is managed by the City of Cape Town's Environmental Resource Management Department, whose offices are at Rietvlei. The Rietvlei wetland system is the central feature, and the Rietvlei Wetlands and Milnerton Lagoon were proclaimed a Nature Area on 3 August 1984. Access is from Milnerton, on the northern edge of Cape Town.

The wetlands here work as a critical buffer between Cape Town's center and the Cape West Coast Biosphere Reserve, protecting endangered lowland habitats that would otherwise disappear. This strategic position makes it essential for preserving ecosystems threatened by urban growth.