Tygerberg Nature Reserve, Protected nature area in Cape Town's northern suburbs, South Africa.

Tygerberg Nature Reserve is a protected area spanning 300 hectares of hills in northern Cape Town. Five hundred plant species grow here, and one hundred bird species make this place their home.

In 1657 the range was named Luipaerts Berghen, Leopard's Mountain, for the spotted look given by heuweltjies, mounds believed to be fossilised termitaria. From 1661 it was known as Tijgerberghen, tijger being the Cape Dutch word for leopard. The reserve was proclaimed in 2016 under new environmental law.

The reserve's Kristo Pienaar Environmental Education Centre, with its library and resource centre, hosts school excursions and education programmes. The name Tygerberg comes from early Dutch settlers' "Gevlekte Luipaertsberg", after vegetation that looked like a spotted animal hide; Afrikaans shortened it to Tierberg, English to Tygerberg.

The reserve lies between Bellville and Plattekloof, and its highest point, the Tygerberg, reaches 415 m, giving a full round view over Cape Town and its northern neighbours. Slopes facing west, south and east border densely built residential areas, while vineyards, including De Grendel, lie near the northern section.

Three plant species exist only within this reserve's boundaries and grow nowhere else in the world. These rare plants are crucial for preserving the Swartland Shale Renosterveld vegetation.