UMkhuze Game Reserve, Game reserve in northern Zululand, South Africa

uMkhuze Game Reserve is a protected area in northern Zululand, KwaZulu-Natal, South Africa, covering a wide range of habitats. It includes acacia savannas, wetlands, riverine forests, and hills rising toward the Lebombo Mountains.

The reserve was first protected in 1912, making it one of the oldest in South Africa. It was later added to the iSimangaliso Wetland Park, which holds UNESCO World Heritage status.

The reserve lies in the traditional Zululand of the KwaZulu-Natal province, and its name is spelled uMkhuze, Mkhuze or Mkuze. The Mkuze River winds along its northern and eastern boundaries, and the reserve is bordered by the Lebombo Mountains on its eastern edge.

The reserve covers 400 square kilometres, with the Mkuze River winding along its northern and eastern boundaries and the Lebombo Mountains rising along the eastern edge. More than 420 bird species have been recorded across its savanna, sand forest, riverine forest, pans and rocky ridges. Hides and viewpoints let visitors watch wildlife on foot without disturbing it.

The reserve protects one of South Africa's rare sand forests, a habitat type found on sandy soils, alongside acacia savannah, mixed woodland, riverine forest, grassland and rocky ridges. The Mkuze River winds along its northern and eastern boundaries, and the eastern edge rises up the slopes of the Lebombo Mountains.