Santa Fe Depot, railway station in downtown San Diego, California, United States

Santa Fe Depot is a railway station in Spanish Colonial Revival style located in San Diego and actively used for train service. The building features multiple tracks, waiting areas, and ticket counters that serve travelers daily.

Santa Fe Depot opened on March 8, 1915, built by the Atchison, Topeka and Santa Fe Railway to replace an 1887 Victorian-style depot and to serve visitors to the Panama–California Exposition. It was renamed San Diego Union Station in 1919 after the San Diego and Arizona Railway completed its own transcontinental line, and Santa Fe resumed solo operation in 1951. The building is listed on the National Register of Historic Places.

The building displays Spanish Colonial design with arches, tilework, and courtyards that reference the missions found throughout the region. Visitors notice these design choices in every area, from waiting rooms to the outdoor platforms.

The depot sits in the Core district of downtown San Diego, with Amtrak California intercity trains, Coaster commuter trains, the San Diego Trolley and Metropolitan Transit System buses all serving it. The main entrance faces the tracks under the arched facade, and the trolley platforms lie beyond the historic building. Allow time to cross between the intercity and trolley sides.

The building preserves original details like hand-made tiles and carved woodwork that are rarely seen in modern stations. These crafted features show the quality of construction from that era.