Santa Ana National Wildlife Refuge, Wildlife refuge and natural landmark in Hidalgo County, Texas.

Santa Ana National Wildlife Refuge covers 2,088 acres (8.45 km²) along the Rio Grande south of Alamo in Hidalgo County, Texas. Its flat ground, from 22 to 34 metres in elevation, holds resacas, mudflats, bottomland forest and upland thorn forest. Tall, slender trees with grey-brown bark rise close together, many draped with long pale strands of hanging moss.

The refuge was established in 1943 as a protected area for migratory birds traveling between North and South America. It earned National Natural Landmark status in 1966 because of its ecological importance to regional wildlife.

The old cemetery within the refuge tells the story of early settlers and workers who lived in this region. Walking past the 30 graves offers insight into how people built their lives along the Rio Grande.

The refuge is open daily from sunrise to sunset with multiple trails suitable for different fitness levels and interests. Bring plenty of water and wear good walking shoes, as the climate can be hot and humid.

This location marks the northern edge where many Central and South American animal species reach the end of their natural range. Over 397 bird species and 300 butterfly varieties make appearances here, making it an exceptional spot for observing tropical wildlife in Texas.