Joe Odom House, Historic house on East Jones Street in Savannah, United States.

The Joe Odom House is a house at 16 East Jones Street, built in 1847 for Eliza Ann Jewett. It is one of the earliest constructions on the street, together with 18 East Jones Street, and lies within the Savannah Historic District. Mary Lane Morrison, surveying for the Historic Savannah Foundation, rated the building of significant status.

The house was built in 1847 for Eliza Ann Jewett and later became home to attorney and musician Joe Odom. Its history connects Savannah's early residential past with the region's 20th-century cultural developments.

Joe Odom, an attorney turned musician, lived in the house and appears in John Berendt's 1994 nonfiction novel 'Midnight in the Garden of Good and Evil', though Odom died three years before it was published. The book's portrait of Savannah made the address familiar to readers.

The house sits one block south of Madison Square in the heart of Savannah's Historic District. The location is easily accessible and falls along typical walking routes for exploring the area.

Odom died three years before John Berendt's 1994 book appeared, so he never saw himself in print. The house he occupied at 16 East Jones Street is one of the two earliest constructions on the street, together with number 18.