400 SW Sixth Avenue, Office building in downtown Portland, United States

400 SW Sixth Avenue is an eleven-story office building in downtown Portland, Oregon, standing 139 feet (42 m) tall with 216,108 square feet of gross leasable space. Its exterior is clad in aluminum and stainless steel, while inside are marble floors, woodwork in the lobbies and elevators, and aluminum touches. The ground floor holds retail space, and the building includes underground parking with 70 spaces and a 50-person conference room.

The building was originally constructed in 1960 as a six-story First National Bank headquarters. It underwent substantial renovations and expansions in the 1980s and 1990s that also transformed its exterior appearance.

The building's name changed with its owners: First National Bank Building, then First Farwest Life Building after the insurer bought it in 1976. A Wells Fargo branch long operated here after First National moved its headquarters in 1972. The ground-floor retail space housed Camera World's flagship store from 1995 to 2016.

The building offers good accessibility with high walkability and transit scores in the downtown area. Parking spaces are available on-site, which makes it convenient for visitors arriving by car.

The 1958 curtain wall of Italian blue glass mosaic squares in aluminum frames was the first of its kind in the Northwest. The 1992 rebuild to eleven stories replaced it with aluminum and stainless steel, so the original cladding survives only in descriptions.