Reno Main Post Office, Postal facility in downtown Reno, United States.

The current Reno Main Post Office occupies a building on Vassar Street, not the 1933 Art Deco structure at 50 South Virginia Street that was sold in 2012 and repurposed. The former main post office, designed by Frederic J. DeLongchamps and built by MacDonald Engineering Co. for $363,660, is listed on the National Register of Historic Places.

The former Reno Main Post Office at 50 South Virginia Street was built in 1933 to designs by Nevada architect Frederic J. DeLongchamps, with MacDonald Engineering Co. of Chicago as contractor at a cost of $363,660. It was listed on the National Register of Historic Places in 1990 as U.S. Post Office-Reno Main. Sold in 2012 to 50 South Virginia LLC, it was converted to retail, restaurant and office space; the current main post office is on Vassar Street.

The former post office at 50 South Virginia Street now houses shops and offices; its lower level, renovated in 2015, is called "The Basement" and holds eateries and retail shops. West Elm opened its first Reno store on the first floor in 2016 and closed it in 2022.

The current main Reno Post Office stands at 2000 Vassar Street, not at the former 50 South Virginia Street building, which became a mixed-use complex in 2012. Visitors heading for postal counter services should go to the Vassar Street address; the Virginia Street building now holds shops, restaurants and offices, including the lower-level food and retail area called "The Basement" opened in 2015.

The original structure was the only post office in Nevada built by the federal government featuring Art Deco architectural elements. This architectural distinction makes it a noteworthy example of federal construction artistry from that era.