Nicopolis ad Nestum, Roman archaeological site near Garmen, Bulgaria.

Nicopolis ad Nestum is a ruined Roman town near the village of Garmen, 7 km east of Gotse Delchev. Excavations have cleared 280 m of fortress walls built in opus mixtum, with the south wall and its four round towers fully studied. In the southeast corner stands a rich dwelling with an inner courtyard and marble colonnade, and next to the south wall are the remains of a bath with hypocaust heating.

Emperor Trajan founded the settlement in 106 AD at the location of the earlier Thracian settlement Alexandroupolis, establishing it as a commemorative city for his military victory. This founding marked the beginning of the site as a major Roman outpost in the region.

The city's name means "City of Victory at the Mesta River," and its coins were struck only once, in 211 AD, under Caracalla and Geta, sometimes showing their mother Julia Domna. Votive reliefs found here depict Zeus, Pluto, Hermes, the Thracian Horseman, Asclepius and Hygieia, the river god Nestos, and the Thracian deities Ares and Dionysus.

The ruins lie just outside the village of Garmen, about 7 km east of Gotse Delchev, on the left bank of the Mesta. The excavated area covers around 13 hectares, with uneven ground and partially preserved walls up to 5–6 m high. Some finds are displayed in the historical museum in Gotse Delchev.

A fragmented stone stela found at the city in 1923 was reassembled and translated in 2020. It carries a Greek letter from Septimius Severus and Caracalla thanking the people for 700,000 denarii; the emperor treated the sum as a gift, though the city had backed one of his rivals in 193 AD.