Chapelle Sainte-Croix de Lyon, Religious chapel in 6th arrondissement of Lyon, France.

Chapelle Sainte-Croix is a neo-Byzantine chapel at 147 rue de Créqui in Lyon's 6th arrondissement, built of light stone with a domed tower and a facade inscription reading "O CRUX AVE SPES UNICA". Its rounded apse holds a white marble altar beneath a gold-coloured chandelier, and four dark wooden doors are set into the wall behind it. A crypt beneath contains the ossuary of victims of 1793 and 1794.

The building was constructed between 1898 and 1901 by architect Paul Pascalon as a memorial to tragic events from 1793 and 1794. This was already the third structure built on this site after earlier monuments had been destroyed.

The chapel is also called chapelle des Martyrs, and on the left wall inside a panel lists the names of victims of the Terror in Lyon, sometimes with their trade, title or status. Masses are still held here regularly, and the Capuchin Fathers who served the chapel from its beginning were replaced in May 1979 by the Missionary Family of Our Lady.

The chapel stands at 147 rue de Créqui, north of Cours Lafayette in the 6th arrondissement. Masses are held regularly, and the crypt with the ossuary of 1793–1794 victims can be visited by appointment. Inside, the left wall carries the list of names of those executed in Lyon during the Terror.

The wall inscription reads "O CRUX AVE SPES UNICA", and the crypt ossuary holds remains from 1793 and 1794; it can be visited by appointment. The tomb of Louis François Perrin de Précy, who led the city's defence during the 63-day siege of 1793, is also kept here.