Maria Santissima del Lume, Catholic church in Palazzo Adriano, Sicily, Italy.

Maria Santissima del Lume is a church in Palazzo Adriano with three interior sections supported by twelve columns. The walls display frescoes of the Twelve Apostles, while the bell tower holds four bells and a mechanical clock from the 20th century.

The church was originally founded in 1604 as a shrine to San Sebastiano but collapsed in 1727. It was rebuilt during the 1740s under the direction of Baron Schirò.

The church was held by the Greek clergy until 26 February 1638, when Cardinal Barberini intervened and it passed to the Latin clergy for administering sacraments. The funeral monument in the counterfacade portrays Baron Schirò, the Greek-rite nobleman who rebuilt it in the 1740s.

The church stands on Piazza Umberto I in the centre of Palazzo Adriano. The main entrance is on the facade with the three statue niches; the side walls are exposed bare stone. The bell tower with its four bells and 20th-century mechanical clock rises alongside. The building was restored after the January 1968 earthquake and after a later facade restoration by the Palermo Superintendency.

The facade's three niches hold statues of Saint Peter, Saint Paul and Saint Michael the Archangel. Inside, the church keeps simulacra of the Madonna di Fatima, Saint Francis of Paola, Saint Anthony of Padua and the Immaculate Conception, and the bell tower has four bells and a 20th-century mechanical clock.