Santissimo Crocefisso, Baroque church in Noto, Italy.

The Santissimo Crocefisso is the largest church in Noto's Piano Alto and the second largest in the city, designed by Rosario Gagliardi in the early 18th century. Its unfinished facade rises above a short, straight staircase and has a recently rebuilt rose window. The interior has three naves, with side altars in marble under small domes, and a dome added around 1901.

Designed by Rosario Gagliardi in the first decades of the 18th century, the church is the largest in Noto's Piano Alto and the second largest in the town. Its dome was built around 1901 and inaugurated a few years later as a Benedictine dome. The rose window was recently rebuilt, replacing a small-windowed fronton section added in the second half of the 20th century.

The left nave holds the Landolina chapel, decorated with stuccoes and frescoes in pink and pale blue that appear nowhere else in the church; it also keeps the reliquary of the Holy Thorn. In the apse stands a gold cross made in 1746 by V. Rotondo to designs by Gagliardi, holding a small painted wooden Christ recovered from Noto Antica and attributed to Saint Luke.

The church is located in Piano Alto, the upper section of Noto, and can be easily reached via the town's stairs and streets. Visitors should remember this is an active place of worship, so respectful behavior is important.

The two lions flanking the main entrance are of Roman origin and are now kept inside the church, not outside. In the apse, the golden cross made in 1746 by V. Rotondo after a design by Gagliardi holds a small case with a painted wooden Christ recovered from Noto Antica and attributed to Saint Luke.