Palazzo Brandolin Rota, Palace in Dorsoduro district, Venice, Italy.

Palazzo Brandolin Rota is a three-story palace facing the Grand Canal with a symmetrical facade marked by nine round-headed openings across its levels. Water access is provided through a distinctive central rounded portal designed for traditional Venetian boats.

The building was constructed in the 17th century originally with two floors and was expanded to its current three-story form during renovations in the mid-18th century. These changes reflected the evolving needs of wealthy families living on the lagoon.

In the 19th century the palace housed the Hotel Universo, run by Franz Edler von Hruschka, the Viennese beekeeping pioneer who bought the building in the early 1870s. The soprano Toti Dal Monte and the poet Robert Browning stayed there for short periods. More recently it held the Circolo Società dell'Unione, one of Italy's last gentlemen's clubs.

The palace stands on the north bank of the Grand Canal in Dorsoduro, between the Gallerie dell'Accademia and Palazzo Contarini Polignac, and is a private home not open to visitors. Its water portal and nine round-headed openings are best seen from a vaporetto or gondola passing on the canal.

The five central openings on each noble floor are joined into a single pentafora, but only the first noble floor has balustrades across all nine openings; on the second floor the balustrade is limited to the pentafora, above which the facade rises into a tympanum with two square single-light windows and a pair of large chimneys.