San Francesco di Paola, Catholic pilgrimage church in Milazzo, Italy.

San Francesco di Paola is a Catholic pilgrimage church on Colle San Biagio in Milazzo, with an adjoining convent of the Minims. Its two-tier facade is framed by Corinthian pilasters and crowned by a curved stele carved with a roundel and the motto "CHARITAS". The 18th-century polychrome marble high altar by Giacomo Amato and Gianfranco Arena has a marquetry paliotto and statues of Faith and Hope.

The sanctuary was built by Francesco di Paola himself between 1464 and 1467 on the ruins of a chapel dedicated to San Biagio dei Ragusei, and was originally dedicated to Jesus and Mary. It was renamed after the saint following his canonisation on 1 May 1519. In 1620 the church was enlarged and its axis reversed, and after the 1693 Val di Noto earthquake it took on late Baroque forms. A fire on 10 May 1908 and the Messina earthquake of 28 December 1908 caused damage.

The sanctuary is the only one in Sicily dedicated to Saint Francis of Paola; the island's other churches honour him but are not sanctuaries. The saint himself founded it between 1464 and 1467, and it was later entrusted to the Minims. A coloured majolica of the saint now marks the spot of the original west entrance.

The sanctuary stands on Colle San Biagio, reached from the road that once linked the San Papino quarter to the walled city; the former western entrance is now marked by a coloured majolica of the saint. The church and the adjoining convent share one continuous facade, with the convent entrances and its five balconies to the left of the church door.

The sanctuary is the only one in Sicily dedicated to Saint Francis of Paola; the island's other places of worship are churches named after him. The saint himself helped build the first temple and monastery here between 1464 and 1467, and the complex only took his name after his canonisation on 1 May 1519.