Santa Maria della Salute, Neo-Gothic church in Mestre, Venice, Italy

Santa Maria della Salute in Mestre is a neo-Gothic church with a brick facade crowned by small pinnacles and a central portal rising into a tracery ogee window. Inside, two low side aisles added in 1982 open through strongly depressed arches, and the presbytery is lit by tall pointed windows.

The church began as the oratory of the Hospital of the Confraternity of the Battuti, founded in 1314 after a donation by Mabilia; the first written record of a church of the hospital dates to 1487. Elevated from oratory to church, it held its first Mass on 15 August 1676, a right formally confirmed by Bishop Paolo Francesco Giustinian in 1777. Rebuilt to a design derived from Raffaele Cattaneo's drawings, it reopened in neo-Gothic form in 1906.

The church is dedicated to the Madonna della Salute, and on 21 November, the feast of the Presentation of the Virgin, a popular festival with committees still takes place. The parish was suppressed in 2017 and the church became a diocesan sanctuary. The interior decoration, mostly Marian, was added after 1978 by the first parish priest.

The sanctuary stands in Mestre, on the mainland, not at the Grand Canal entrance in Venice. The facade faces the street with exposed brick, and the two low side aisles added in 1982 open through very depressed arches. The building belongs to the hospital institution, so parts may be closed for services.

The church keeps the name Santa Maria della Speranza for its 1978 parish, created when Mestre's postwar growth required new parishes. In 2017 Patriarch Francesco Moraglia ended that parish role and raised the building to diocesan sanctuary of the Madonna della Salute.